20.7.1. Prostaglandines, thromboxans and leukotrienes
Prostaglandins was first isolated from the prostate gland, thus called as prostaglandins. Prostaglands have five carbon ring which is originated from the chain of arachidonic acid. Two group of prostaglandin PGE ether soluble and PGF phosphate buffer soluble. Each group (PGE) have subtype PGE1, 2 and 3.
- Prostaglandins regulate the synthesis of intracellular messenger i.e. cyclic AMP (cAMP). cAMP mediates the action of diverse hormones. Prostaglandin affects the cellular and tissue function.
- Prostaglandin stimulate the contraction of smooth muscles of uterus during menstruation.
- Prostaglandin also affect the blood flow to specific organs.
- Prostaglandin elevate the body temperature and cause inflammation and pain.
Thromboxanes contain six membered ring containing ether. They produces by thrombocytes. (platelets) The main role of thromboxane is formation of blood clot. It reduce the blood flow to site of a clot.
Anti inflammatory drug (NSAIDs) :
Aspirin, ibuprofen and meclofenamate inhibit prostaglandin H2 synthesis. Which catalyses the early step in the path way from arachidonate to prostaglandins and thromboxans.
Leukotrienes are hydroxy fatty acid derivative of arachidonic acid. Leukotrienes do not contain a ring structure. Leukotrienes is 1st found in leukocytes. Leukotrienes are distinguished by containing a conjugated triene double-bond arrangement. They are powerful biological molecules. e.g., Leukotriene D4, derived from leukotriene A4.
It induces the contraction in the muscle lining to the lung. Leukotrienes causes asthmatic attacks because of the over production.
Body contain a variety of lipids stored in its structure which performs a variety of functions. Fatty acids are the storage material which produces a large amount of energy upon oxidation. Fats transported inside the body in the form of lipoproteins which can be very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high density lipoproteins (HDL).